Consequently, in order to follow this path of research, the aim of this study was to investigate the correlation of ADC values with cell cycle and proliferative biomarkers (p53, p21, Ki67) and to establish its potential role as a noninvasive biomarker for prediction of cell cycle, proliferative activity and biological aggressiveness in bladder cancer. The gene discussed is TP53; the disease is urinary bladder carcinoma.