Many studies in the last years showed increased S100B levels in the serum/plasma of patients with schizophrenia, as reported in older meta-analyses by Schroeter et al. [23], [24], who report in addition no differences in S100B levels in medicated end drug-free patients and take into account the effect of age including only studies with age-matched controls. The gene discussed is S100B; the disease is schizophrenia.