Since loss or inactivation of FOXO3 activity is associated with tumor progression, drug resistance, and decreased patient survival in multiple cancers [19], [46], [47], [48], [49], we investigated the impact of FOXO3 protein loss on cellular migration and invasion of two independent immortalized non-transformed urothelial cell lines, UROsta and SV-HUC. The gene discussed is FOXO3; the disease is neoplasm.