Considering the observed preliminary up-regulation of specific miRNAs by ascorbate (possibly via its novel DNMT inhibitory activity) governing a broad spectrum of tumor-suppressive effects including apoptosis induction, antiproliferative activity, and decrease of cancer cell invasion, this novel epigenetic signature of ascorbate might open the door for the exploration of ascorbate in combination with other classical or even epigenetically active molecules for cancer therapy (90) and therefore warrants further pre-clinical and clinical investigation. Here, DNMT1 is linked to cancer.