Studies by Khor et al., looking at variant alleles of CISH gene polymorphisms and susceptibility to infectious diseases found that the minor alleles of three SNPs (−292, +1320, and +3415) were associated with increased susceptibility to TB in Malawian population and further reported that TB susceptibility in the Gambia was accounted for by more than one SNP, implying a highly genetically diverse population [66]. The gene discussed is CISH; the disease is tuberculosis.