RAF1 and hepatocellular carcinoma: The standard treatment for advanced HCC (BCLC stage C) is sorafenib, an oral multikinase inhibitor that inhibits the following: i) Serine-threonine kinases, Raf-1 and B-Raf, of the Raf/MEK/ERK signaling pathway; and ii) the receptor tyrosine kinase activity of VEGFR1,2 and 3, PDGFR-β, c-Kit, Flt-3 and RET (2,3).