CDKN2B and colorectal carcinoma: Fig. 6A shows that the expression of CDKN2B protein levels was increased in the cells with anti-miR-31 or anti-miR-708, compared with the anti-NC cells (Fig. 6A and B). In addition, CDKN2B protein levels were investigated in five CRC tissues and the adjacent healthy tissues. Fig. 6C indicates that the CDKN2B levels were lower in the CRC tissue samples, which contrasts with the miR-31 and miR-708 expression levels. Taken together, these results indicate that CDKN2B is negatively regulated by miR-31 and miR-708. This negative regulation is also schematically demonstrated in Fig. 7.