The ORs for predicting the presence of CRC using the methylation of SFRP2, GATA4, GATA5, NDRG4 and VIM were 12.00 (95% CI, 3.76–38.30; P<0.01), 14.25 (95% CI, 3.13–64.97;P<0.01), 24.62 (95% CI, 8.33–72.74; P<0.01), 15.60 (95% CI, 1.97–123.36; P=0.001) and 3.95 (95% CI, 1.43–10.93; P=0.006), respectively. This evidence concerns the gene NDRG4 and colorectal carcinoma.