Previous studies investigating the detection of a combination of O(6)-methylguanine-DNA methyltransferase, human Mut L homolog 1 and vimentin (VIM) gene methylation in fecal DNA from patients with CRC, adenoma and normal individuals, reported a sensitivity of 75% in CRC and 60% in adenoma patients, and a specificity of 86%, respectively (5). Here, VIM is linked to adenoma.