Of note, tumor size (P=0.018), histological type (P=0.025), TNM stage (P=0.002), lymph node metastasis (P=0.008) and distant metastasis (P=0.018) were found to be significantly associated with RNF180 methylation, indicating that this epigenetic alteration may be a valuable marker for the prognosis of GC patients. Here, RNF180 is linked to gastric cancer.