Furthermore, if RNF180 and DAPK1 methylation were combined, the OR (95% CI) for cancer prediction [OR, 4.86 (2.03–11.66); P=0.0003] was similar to that of the RNF180 methylation [OR, 4.40 (1.82–10.65); P=0.0007] alone and to that of the methylation of the three genes combined [OR, 4.40 (1.61–12.03); P=0.0026]. Here, RNF180 is linked to cancer.