The ORs (95% CI) for predicting the presence of GC using the RNF180 (P=0.0007), DAPK1 (P=0.0394) and SFRP2 methylation statuses (P=0.0036) were 4.40 (1.82–10.65), 2.41 (1.03–5.63) and 3.42 (1.47–7.92), respectively (Table IV). The gene discussed is SFRP2; the disease is gastric cancer.