A detailed TACSTD2 signaling network in cancer growth was further elucidated by Guerra et al (21); TACSTD2 upregulation was shown to subsequently drive the expression and activation of CREB1, Jun, NF-kB, Rb, STAT1 and STAT3 through induction of the cyclin D1 and ERK/MEK pathways (8). Here, CREB1 is linked to cancer.