Further studies by Sivula et al (19) and Bailey et al (20) have shown that by regulating the migration of tumor cells, enhancing the degradation of extracellular matrix and other activities, COX-2 increased the invasive capacity of cancer cells, further promoting the invasion of blood and lymphatic vessels, enhancing the transfer of cells to the lymph nodes and distant organs. The gene discussed is PTGS2; the disease is neoplasm.