In addition, Bamba et al (26) revealed that COX-2 acts on the associated receptors by promoting the synthesis of PGs, including PEG2 and 15-deoxy-PG J2, or induces the increase of VEGF-A-based angiogenesis factor expression by entering the nucleus directly via nuclear receptors to induce the formation of tumor blood vessels. This evidence concerns the gene VEGFA and neoplasm.