Certain studies insist that Cav-1 is downregulated and serves as a tumor suppressor in breast cancer (71–73), GC (74), hepatic cancer (75) and mucoepidermoid carcinoma (MEC) of the salivary glands (76); while other studies suggest that the expression levels of Cav-1 are upregulated, consistent with advanced tumor stage, high histological type and the metastasis of human cancer cells, including esophagus (77,78), pancreatic (79), renal (80), prostate (81) and colorectal (82) cancer. The gene discussed is CAV1; the disease is liver cancer.