Although Cav-1 levels in lung tumor tissues are significantly lower than in tumor-free lung tissues (91,92,100–102), the expression of Cav-1 in lung tumor tissues is markedly higher in patients with lymph node metastasis (92,93,100) and advanced tumor stage (93,100,103). Here, CAV1 is linked to metastatic malignant neoplasm in the lymph nodes.