CAV1 and intrahepatic cholangiocarcinoma: The ICC analysis of several cohorts of esophageal squamous cell carcinoma samples (range, 47–130 samples) (77,78), has identified that positive Cav-1 immunostaining positively correlates with pathological stage (pT, pN and pM stages) and lymphatic or vein invasion, and predicts a significantly shorter overall survival rate.