In a combined study of 358 resected breast cancers cocultured with Cav-1 siRNA-treated fibroblasts and the MDA-MB-468 cell line, Simpkins et al (34) identified that the loss of Cav-1 expression significantly correlates with decreased breast cancer-specific and disease-free survival (P=0.01), through promotion of breast cancer cell invasion. This evidence concerns the gene CAV1 and breast cancer.