Yang et al (110) found that Cav-1 was overexpressed in 41.7% (15 out of 36 patients) of human high-grade prostatic intraepithelial neoplasia (HGPIN) specimens and further revealed a highly significant correlation between Cav-1 (+) HGPIN and Cav-1 (+) PC. This evidence concerns the gene CAV1 and pachyonychia congenita.