CAV1 and pachyonychia congenita: Whereas Steiner et al (111) found that the number of caveolae was significantly reduced in LNCaP and PC3 cells (P<0.0001), which implied that the downregulation of Cav-1 occurs with the development of PC, while the downregulation of Cav-1 in PC tissues conversely correlates with pT category (P=0.006) and Gleason score (P=0.041).