Additionally, Yan et al (78) identified that the Cav-1 mRNA expression in hepatitis B virus-related hepatocellular carcinoma (HCC) cells was found to negatively correlate with the tumor size, major venous invasion, single or multiple tumors, pTNM staging and factors associated with the prognosis of HCC, inconsistent with other studies (85,86). This evidence concerns the gene CAV1 and hepatocellular carcinoma.