The expression of many lipogenic genes, such as acetyl-CoA carboxylase (ACC) and stearoyl-CoA desaturase (SCD), is transcriptionally regulated by sterol regulatory element-binding protein-1 (SREBP-1) and then activates expression of the target gene in obesity [8]. The gene discussed is SREBF1; the disease is obesity due to melanocortin 4 receptor deficiency.