CD8A and malaria: However, due to the absence of a direct method to identify and phenotype malaria vaccine-induced intrahepatic CD8+ T cells in humans and non-human primates during pre-clinical and clinical tests, it should be important to determine whether the levels of antigen-specific CD8+ T cells found in the liver correlates with the peripheral CD8+ T cell responses from PBMC blood found in murine models, using a subunit vaccine for proof-of-concept.