It is notable that most mouse models of DCM-causing mutations show little or no phenotype at rest (ACTC E361G, TNNT2 ΔK210, MYBPC3 knock-in (KI) (see Table 2) and TTN KI Gramlich et al., 2009), especially when heterozygous like the patients with these mutations. The gene discussed is TTN; the disease is familial dilated cardiomyopathy.