HPGDS and hypertensive disorder: Specific markers of oxidative stress would target specific pathways of ROS production and may reveal more regarding mechanisms within each hypertensive disorder, The 8-iso-prostaglandin F2α (PGF2α) is known as an in vivo biomarker of oxidative stress and can be studied in both plasma and urine to give more complete information; erythrocyte glutathione-S-transferases (Orhan et al., 2003) as well as glutathione peroxidases (Orhan et al., 2003) are also often used as oxidative stress markers.