In this Research Topic of Frontiers in Pharmacology named The Cell Types of Fibrosis, Lee et al. (2014) demonstrate that treatment with a Cav-1 scaffolding domain peptide (CSD) spanning amino acids 82–101 of the full protein inhibits dermal fibrosis and lipodystrophy in a mouse model of bleomycin-induced fibrosis that closely mimic the histopathology of skin observed in clinical situations of SSc. The gene discussed is CAV1; the disease is fibrosis.