We also show here that the hippocampus is especially sensitive to the effects of dietary folate deficiency, which resulted in nearly 30% loss of LCMT1, 50% loss of methylated PP2Ac, and concomitant doubling of p-Tau (PHF-1) levels in wt mice fed the LF diet, relative to control animals fed the NF diet. Here, LCMT1 is linked to folate deficiency.