While MTHFR deficiency-induced cerebellar p-Tau changes may not directly relate to the neurodegenerative process in AD, it is worth mentioning that low concentrations of 5-MTHF in the cerebrospinal fluid have been linked to cerebellar atrophy and neurological disorders in children (Grapp et al., 2012). This evidence concerns the gene MTHFR and nervous system disorder.