In this regard, studies in the Fragile-X amygdala showed that in conditional KO animals, where FMRP is exclusively expressed in inhibitory interneuron populations, that inhibitory neurotransmission dysfunction is comprised of both presynaptic and postsynaptic components (Vislay et al., 2013); therefore suggesting an important role of interneurons in the development and function of this particular brain region in FXS (Olmos-Serrano et al., 2010; Vislay et al., 2013). This evidence concerns the gene FMR1 and fragile X syndrome.