CALB1 and fragile X syndrome: Finally, molecular markers such as neuronal nitric oxide synthetase and calbindin are downregulated in FXS (Real et al., 2011; Xu et al., 2012a; Giráldez-Pérez et al., 2013), which suggest that interneurons such as ivy cells, neurogliaform cells (NGF) and bipolar interneuron populations can be diminished in brain circuits of FXS.