Interestingly, complete absence of NPRA causes hypertension in mice and leads to altered renin and ANG II levels, cardiac hypertrophy, and lethal vascular events similar to those seen in untreated human hypertensive patients (Oliver et al., 1997; Shi et al., 2001, 2003; Zhao et al., 2007). Here, NPR1 is linked to hypertensive disorder.