The studies detailing the Npr1 (coding for NPRA) gene-disruption in mice have revealed the functional significance of NPRA in the control of blood pressure and cardiovascular disease states (Oliver et al., 1997; Shi et al., 2001; Holtwick et al., 2002; Vellaichamy et al., 2005; Kishimoto et al., 2011; Pandey, 2011; Yoshihara et al., 2014). Here, NPR1 is linked to cardiovascular disorder.