Genetic mouse models with disruption of both Nppa and Npr1 genes have provided strong support for the role of this hormone-receptor system in the regulation of blood pressure, cardiac hypertrophy, and other physiological functions (John et al., 1995; Lopez et al., 1995; Oliver et al., 1997, 1998; Melo et al., 1999; Pandey et al., 1999; Shi et al., 2001, 2003; Holtwick et al., 2002; Vellaichamy et al., 2005; Kishimoto et al., 2011; Pandey, 2011). Here, NPR1 is linked to cardiac hypertrophy.