Both BNP and NT-proBNP seem to provide an ideal tool to be utilized as blood tests to diagnose cardiac disorders in patients with high risk of heart failure, diabetes, chronic kidney disease, and coronary artery disease (Khan et al., 2006; Freestone et al., 2008; Czucz et al., 2011; Ganem et al., 2011). This evidence concerns the gene NPPB and diabetes mellitus.