MCC and Miyoshi myopathy: In contrast to the cell cycle blocking and proliferation inhibitory effects of MCC overexpression reported in fibroblasts and CRCs [20,31,32,35], we found that overexpression of MCC in human MM cell line 8226 cells, which express endogenous MCC at relatively modest levels, did not affect cell cycle progression, cell proliferation, or cell survival at all (data not shown).