Paradoxically, in contrary to the up-regulation of MCC in B cell neoplasms, the MCC gene is frequently deleted, mutated, or silenced in other human cancers, including colorectal cancer [14–17,19,20,22], lung cancer [17,23], gastric carcinoma [24], esophageal cancer [25], and hepatocellular carcinoma [26,27]. This evidence concerns the gene MCC and cancer.