Results of cell cycle analysis demonstrated that transduction of MCC shRNA 1332 or 2689 resulted in a dramatic decrease in the proliferating cell population (S/G2/M phase: 2n < DNA content ≤ 4n) and an increase in the apoptotic cell population (DNA content < 2n) in human MM cells (Figure 5A). This evidence concerns the gene MCC and Miyoshi myopathy.