They found that BAF57 deregulation circumvented androgen-mediated signaling, upregulated α2 integrin expression, altered other SWI/SNF complex components at the α2 integrin locus and conferred a prometastatic migratory advantage on PCa cells that could contribute to castration resistance and bone metastasis in patients [60]. The gene discussed is SMARCE1; the disease is posterior cortical atrophy.