The objectives of this study were: 1) To investigate if RANKL overexpression promotes overexpression of integrins that support the adhesion of PCa cells to bone matrix proteins; 2) To determine if the levels of integrin expression are affected by growing PCa cells in 3-D suspension culture; 3) To determine if AR can be restored in RANKL-overexpressing LNCaP cells, and whether this restored AR modulates integrin expression/function to increase the growth, adhesion and survival of PCa cells in bone. Here, TNFSF11 is linked to posterior cortical atrophy.