Our analysis of miRNA targets has led to the identification of genes that may play a key role in the transformation process and in maintaining the phenotype in lymphoma cells, including MKI67 and TRAF, targeted by at least three of the downregulated miRNAs, and others like CCND1, STIL and PBK targeted by miR-150, miR-199a-5p and miR-28, respectively. This evidence concerns the gene PBK and lymphoma.