The involvement of NF-kB in miRNA deregulation was demonstrated by the enrichment of the binding motifs of the NF-kB complex subunits among the genomic sequences of the miRNAs undergoing expression changes, NF-kB p65 binding to miRNA promoters from ChIP-seq data and the finding that p65 binds the promoters of miRNAs following EBV infection. This evidence concerns the gene RELA and Epstein-Barr virus infection.