In 2011, the BC protocol for SP included: diagnostic workup for EBC; local and systemic treatment, such as breast and axillary surgery (breast conservation surgery/mastectomy and SLNB/ALND); and, when appropriate, adjuvant radiation therapy, chemotherapy, endocrine therapy (ET) and trastuzumab (for HER2 positive BC) [8, 9]. This evidence concerns the gene ERBB2 and breast cancer.