In addition, the numbers of TFR cells were positively correlated with the numbers of CD4+CD25+Foxp3+ Tregs and CD5+CD19+CD1dhighIL-10+ Bregs in both CHB (R = 0.4613, p = 0.0003; R = 0.4245, p = 0.0009) and CHC (R = 0.5417, p = 0.0008; R = 0.4435, p = 0.0100) patients, respectively. Here, CD4 is linked to cryohydrocytosis.