However, the numbers of CD5+CD19+, CD5+CD19+CD1dhigh B cells and CD5+CD19+CD1dhighIL-10+ Bregs in both the CHB and CHC patients were significantly greater than those in the HC (p < 0.05) although there was no significant difference in the numbers of CD5+CD19+CD1dhighIL-10+ Bregs between the CHB and CHC patients. Here, CD5 is linked to cryohydrocytosis.