Interestingly, the numbers of CD4+CD25+Foxp3+ Tregs were positively correlated with the numbers of CD5+CD19+CD1dhighIL-10+ Bregs in the CHB (R = 0.7213, p < 0.0001) and CHC (R = 0.7432, p < 0.0001) patients. The gene discussed is CD4; the disease is cryohydrocytosis.