Our data indicated that significantly increased numbers of circulating IL-10+ Bregs, TFR, TFH and Tregs in CHB and CHC patients and the numbers of IL-10+ Bregs and TFR cells were correlated positively with the levels of serum HBV DNA, HCV RNA, and ALT in CHB or CHC patients, respectively. Here, TFRC is linked to cryohydrocytosis.