Our data indicated that significantly increased numbers of circulating IL-10+ Bregs, TFR, TFH and Tregs in CHB and CHC patients and the numbers of IL-10+ Bregs and TFR cells were correlated positively with the levels of serum HBV DNA, HCV RNA, and ALT in CHB or CHC patients, respectively. This evidence concerns the gene GPT and cryohydrocytosis.