Analysis of CHC patients indicated that the numbers of circulating CD5+CD19+CD1dhighIL-10+ Bregs were correlated positively with the levels of HCV RNA (R = 0.5214, p = 0.0024, Figure 5B), ALT (R = 0.4262, p = 0.0190) and AST (R = 0.4211, p = 0.0121). Here, CD5 is linked to cryohydrocytosis.