CHOP resulted down-regulated in patients with family history of cancer (F1: fold-change = 0.11, Q1-Q3 = 0.09-0.16 vs F0: fold-change = 1.23, Q1-Q3 = 0.24-2.39; p = 0.044) and over-expressed in patients who had a previous neoplasia (PN1: fold-change = 31.77, Q1-Q3 = 1.57-61.98 vs PN0: fold-change = 0.66, Q1-Q3 = 0.13-1.93; p = 0.033). This evidence concerns the gene DDIT3 and cancer.