In animal models, HSF1 is important for p53 mutation-induced lymphoma (15), diethylnitrosamine (DEN)-induced hepatocellular carcinoma (16), dimethylbenz(a)anthracene (DMBA)-tetradecanoylphorbol acetate (TPA)-induced skin cancer (4) and human epidermal growth factor receptor 2 (Her2)-induced breast cancer (5,9). This evidence concerns the gene ERBB2 and hepatocellular carcinoma.