Heat shock-activated HSF1 is mainly responsive to the expression of heat shock proteins, while activation of HSF1 in tumor tissues is predominantly responsible for controlling the expression of non-heat shock proteins, e.g. CKS2, LY6K, RBM23, CCT6A, CKS1B, ST13 and EIF4A2. The gene discussed is RBM23; the disease is neoplasm.