Among the predicted genes (such as vascular endothelial growth factor A, microfibrillar-associated protein 3, Kv channel interacting protein 1 and TNF receptor-associated factor 3) that were targeted by miR-361-5p, vascular endothelial growth factor A was found to be a key point in a signaling pathway for vasculogenesis and endothelial cell growth, cell migration, cell apoptosis and arteriosclerosis. The gene discussed is MFAP3; the disease is arteriosclerosis.