Amongst candidate cytokines, IL-6 has particularly strong credentials as a mediator of physiological or pathological matrix expansion, inducing GAG production amongst various cell types and in diverse disease states, including Grave's disease and gingival hyperplasia [17]–[19], while hepatic regeneration does not occur in IL-6 deficient mice unless they receive exogenous IL-6 [20]. The gene discussed is IL6; the disease is gingival disorder.