To date, the binding of human FXR in primary human hepatocytes (PHHs) or hepatoma cell lines has been characterized to limited genes, including ABCB4 (ATP-binding cassette, sub-family B, member 4), ABCB11, FGF19 (fibroblast growth factor 19), ICAM1 (intercellular adhesion molecule 1), and NR0B2[4], [22]–[25]. The gene discussed is FGF19; the disease is hepatocellular carcinoma.