SOST and hyperostosis corticalis generalisata: There are many examples of such findings providing important insights into musculoskeletal development and pathology, and many current treatments have been developed based on genetic discoveries—for example the development of anti-sclerostin antibodies based on the discovery that the high bone mass conditions of sclerosteosis and van Buchem’s disease arise from mutations in the gene for sclerostin [35,36].