In our 3D CRC model, strongly reduced cIAP1 levels were detected 24 hours after SM83 treatment, whereas cIAP2 was only transiently downregulated, in accordance with the finding that cIAP1 downregulation causes cIAP2 upregulation by non-canonical NFkappaB activation [32]. This evidence concerns the gene NFKB1 and colorectal carcinoma.