TEAD2 and multiple acyl-CoA dehydrogenase deficiency: It is noteworthy that such mixed effects have also been identified in other inborn errors of metabolism, that for instance include the ETF variants p. βAsp128Asn and p. βArg191Cys associated with mild cases of multiple acyl-CoA dehydrogenation deficiency (MADD) [21], [22]; the MCAD p.Thr193Ala variant with altered catalytic activity, folding and stability associated with MCAD deficiency [23], [24]; and two polymorphic SCAD variants, p. Gly185Ser and p. Arg147Trp, which are susceptible to present a decreased activity and thermal stability [25].