Although a subset of medulloblastomas (∼21%) exhibit OTX2 genomic copy number gain [5], nearly all non-Shh medulloblastomas (∼74% of all medulloblastomas) overexpress OTX2 [2], [5], [17]; thus, there remains a substantial proportion of these tumors that aberrantly express this oncogene in the context of normal OTX2 genomic copy number. The gene discussed is SHH; the disease is medulloblastoma.