Strikingly, many of the DHS sites in medulloblastoma were also present in a retinoblastoma cell line [Weri-Rb cells, data from [36]], with medulloblastoma exhibiting only two unique DHS sites (out of 10 prominent DHS sites) at the OTX2 locus relative to retinoblastoma, and retinoblastoma exhibiting only four unique DHS sites (of 14 prominent DHS sites; Fig. S1A). This evidence concerns the gene RB1 and retinoblastoma.