While OTX2 is expressed in some tissues giving rise to midbrain and hindbrain [9] as well as in a subset of cerebellar granule neuron precursors [8], [15], which are known cellular origins of medulloblastoma, it is unclear whether OTX2 expression is inherited from the tumor cell of origin or rather induced over the course of transformation. The gene discussed is OTX2; the disease is medulloblastoma.