However, the expression patterns of known trans-acting Otx2 developmental regulators cannot in any case explain the expression pattern of OTX2 in medulloblastoma (Fig. S5), and mapping all previously-described Otx2 developmental enhancers onto the human genome reveals minimal overlap between these enhancers and medulloblastoma DHS sites (Fig. S1A). This evidence concerns the gene OTX2 and medulloblastoma.