OTX2 and medulloblastoma: Notably, the minimally-required region of DHS 4 contains a highly-scoring OTX2 binding motif (p = 1.36e−4)(Fig. 3G) that exhibits a prominent DNase footprint [37] in medulloblastoma cells (Fig. S3B), strongly implicating direct binding of OTX2 protein to this region.