TNFRSF10B and melanoma: While 20(S)-Rg3 promotes TRAIL-induced apoptosis in hepatocellular carcinoma cells via C/EBP homology protein-mediated DR5 upregulation [41], it decimates lung metastasis produced by B16-BL6 melanoma in syngeneic mice through inhibiting angiogenesis and reducing cancer cell adhesion and invasion [30].