PKM and colorectal cancer: PKM2 has been shown to act as a marker for: renal cell carcinoma (RCC) [26], [27], testicular cancer [28], breast cancer [29], urological tumors [30], lung carcinoma, cervical cancer, and gastrointestinal tumors [31]; and with a possible detection in the feces of patients with gastric and colorectal cancers [32].