RYR2 and Alzheimer disease: Several studies have reported alterations of the expression and the function of RyR in human AD-affected brains, in cells expressing familial AD-linked mutations on the β amyloid precursor protein (βAPP) and presenilins (the catalytic core in γ-secretase complexes cleaving the βAPP, thereby generating amyloid β peptides), and in brain of transgenic AD mice models.