Two independent studies, the first with miR-128 in glioma [131] and the second with miR-145 in colon cancer tissues [132], demonstrated that decreased p70S6K1 expression, mediated by these miRNAs, inhibits cell proliferation, tumour growth, and angiogenesis which is thought to be because HIF-1α and VEGF are both downstream to this molecule. The gene discussed is VEGFA; the disease is malignant colon neoplasm.