Further, supporting this, the same group showed that the addition of anti-miR-132 inhibited angiogenesis in wild-type mice but not in mice with an inducible Rasa1 (encoding p120RasGAP) deletion; in another experiment, targeted delivery of anti-miR-132 nanoparticles to the vessels restored p120RasGAP expression in the tumour endothelium, suppressing angiogenesis and decreasing the tumour burden in an orthotopic xenograft mouse model of human breast carcinoma. This evidence concerns the gene RASA1 and breast carcinoma.