KLK3 and posterior cortical atrophy: In spite of several clinical parameters, such as serum prostate specific antigen (PSA) levels, age and underlying health of men, the extent of tumor spread, appearance under the microscope, and the response to initial treatment, which may provide some prognostic utility in the treatment settings, there are currently no definitive clinical methods that can reliably predict the responses to clinical therapies for PCa [4].