IL4 and asthma: Indeed, OGR1-deficient mice are resistant to the cardinal features of asthma, including airway eosinophilia, AHR, and goblet cell metaplasia, in association with a remarkable inhibition of the production of Th2 cytokines, including IL-4, IL-5, and IL-13, and OVA-specific IgE in an OVA-induced asthma model [59].