Allergenicity, functional mimicry of environmental contaminants and physical/chemical elements resembling TLR ligands; Dysregulation of the regulatory B cell (IL-10 producing, CD5+ B cells) through modulation of TLR signaling; Molecular motifs of adjuvants and their physiological receptors that are associated with clinical manifestation of autoimmunity; Genomic predisposition to innate immunity dysfunctions. Here, IL10 is linked to Autoimmunity.