Immunization with DNA and MVA encoding SIV genes preserved colorectal CD4+ CM T cells and protected macaques from progression to AIDS following an IR SIVmac251 challenge [38] while in female macaques resistance to Ivag SIVmac251 infection and persistent suppression of SIV viremia was associated with vaginal CD8+ T cells and mucosal IgA responses [10]. The gene discussed is CD4; the disease is infection.