Tumor incidence was also noted in 20% of glands lacking three of the four GSK-3 genes, that is, of genotype WAP-Cre; GSK-3α−/−; GSK-3βFL/+; or WAP-Cre; GSK-3α−/+; GSK-3βFL/FL (referred to as 3⁄4 WAP-DKO) arising with a median latency of 14 months, which was statistically significantly different from WAP-DKO (P=0.0015 log-rank test, P=0.0075 Wilcoxon test) (Table 1, Figure 4c). The gene discussed is GSK3A; the disease is neoplasm.