The hepatic promoter methylation of the peroxisome proliferative activated receptor (PPAR)-gamma coactivator one alpha (PGC1-α) gene, a key transcriptional regulator of mitochondrial fatty acid oxidation, not only correlated with the status of peripheral insulin resistance, but also associated with the fasting insulin levels of NAFLD patients [54]. Here, PPARGC1A is linked to Insulin resistance.