Together, it is plausible that mutant seipin mislocalization to the nuclear envelope along with its association with lipin 1 may inhibit the suppressive activity of lipin 1 on NFATc4, leading to subsequent activation of inflammation in lipodystrophy, as also observed in obesity associated inflammation (Figure 2B) [76]. This evidence concerns the gene LPIN1 and obesity due to melanocortin 4 receptor deficiency.