Many studies on VDR gene polymorphisms and sporadic CRC have shown a reduced risk of CRC for patients with the B allele of BsmI, f allele of FokI and A allele of ApaI, and t allele of TaqI, which are associated with higher activity of the vitamin D receptor, but the influence of SNPs on cancerogenesis may be modified by many elements including the environment, lifestyle, and many other genetic factors [2, 8, 16]. The gene discussed is VDR; the disease is colorectal carcinoma.