GLP1R and myocardial ischemia: Recently, GLP-1 has been shown to reduce an infarct size in both in vitro and in vivo animal models of cardiac ischemia/reperfusion injury [5–7] and exendin-4 (Ex-4), an exogenous GLP-1R agonist isolated form the Gila monster lizard [8], has reported to have very similar effects [4,9,10].