Besides, when NME2 expression vector was co-transfected with shPIWIL2, the specific band indicating NME2/PIWIL2/G4-motif complex remained undetected (Figure 4B), suggesting that interaction between NME2 and G4-motif complex is PIWIL2-dependent in tumor cells. Here, PIWIL2 is linked to neoplasm.