To define whether rapamycin-induced increase in eIF4E phosphorylation is mediated by Mnk1 or Mnk2, we knocked down Mnk1 or Mnk2 in Daoy medulloblastoma cells, and examined the effects of such knockdown on rapamycin-inducible eIF4E phosphorylation. This evidence concerns the gene MKNK2 and medulloblastoma.