Further, since JNK mediates cell death caused by ROS accumulation via sustained PARP activation [24, 25], PL-induced GSTP1 inhibition and pJNK activation resulted in part in PARP activation; however, the knockdown of GSTP1 itself did not significantly affect PARP activation, cellular ROS levels, or survival in AMC-HN3 cancer cells. The gene discussed is MAPK8; the disease is cancer.